AI Agent & Copilot Podcast: Marie Wiese on Real-World AI Adoption, Innovation, and the Human Side of Change

Marie Wiese, CEO of Marketing Copilot and Microsoft MVP, joins John Siefert in this episode of the AI Agent & Copilot Podcast. Wiese highlights the transformational impact of AI on businesses and individuals, underscoring the importance of change management and innovation. She also details a new book release and what the AI Agent & Copilot Summit will provide attendees.

Key Takeaways

• AI’s progress: Wiese expresses excitement to return to the event after a year to hear real case studies on how people have embraced AI, especially appreciating the human and change management side of this transformational journey. Specifically, she’s eager to learn where organizations have tested, scaled, or faced pushback over the past 12 months, noting that adopting AI is an ongoing, iterative process.
• Curating the agenda: “I think my number one view of all of the submissions was around innovation,” notes Wiese, who played a role as a Programming Committee Board member, selecting sessions for the 2026 AI Agent & Copilot Summit agenda. In her process, she looked for examples of where organizations have truly innovated with this technology. “I want honest, too. You know, ‘this is what we tried. It didn’t work, but we came back at it, here’s how'”.
• AI’s impact on women in tech: On Thursday, March 19, Wiese will lead a Fireside Chat around her new book, “You’re on Mute.” The book explores whether AI has actually helped women enter and thrive in the tech industry amid persistent adoption and trust gaps. Through stories from contributors, it examines AI’s impact on leveling the playing field and encourages more women to see AI as a path into tech.
• Event expectations: The real power of conferences and events comes from being together, notes Wiese. With the lineup of speakers, she believes attendees will gain access to candid insights and meaningful peer connections.

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AI Agent & Copilot Summit is an AI-first event to define opportunities, impact, and outcomes with Microsoft Copilot and agents. Building on its 2025 success, the 2026 event takes place March 17-19 in San Diego. Get more details.